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Important safety information

Indication

iovera° applies freezing cold to peripheral nerve tissue to block and/or relieve pain for up to 90 days. It should not be used to treat central nervous system tissue.

Important safety information

The iovera° system should not be used in people with the following conditions:

  • Do not receive treatment with ioveraº if you experience hypersensitivity to cold or have open and/or infected wounds near the treatment site.
  • You may experience bruising, swelling, inflammation and/or redness, local pain and/or tenderness, and altered feeling at the site of application.
  • In treatment area(s), you may experience damage to the skin, skin darkening or lightening, and dimples in the skin.
  • You may experience a temporary loss of your ability to use your muscles normally outside of the treatment area.
  • Talk to your doctor before receiving treatment with ioveraº.
More +

Indication

iovera° applies freezing cold to peripheral nerve tissue to block and/or relieve pain for up to 90 days. It should not be used to treat central nervous system tissue.

Important Safety Information

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© 2026 Pacira Pharmaceuticals, Inc., a wholly owned subsidiary of Pacira BioSciences, Inc. All rights reserved. iovera°
is a registered trademark of Pacira CryoTech, Inc., a wholly owned subsidiary of Pacira BioSciences, Inc. PP-IO-US-0889 v2 10/25