iovera° treatment is simple and only takes about 30 minutes

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First, a numbing agent (topical or injected) is applied to minimize discomfort during treatment. iovera° treatment is not painful.

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Then, a small probe (we call it a “Smart Tip”) is inserted into the skin.

Under the skin, a precise cold zone forms, which temporarily freezes the targeted nerve. This immediately blocks the nerve from sending pain signals to your brain for up to 90 days.

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Your doctor will repeat this process until the targeted nerve is blocked. The entire treatment takes about 30 minutes.

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A novel way to relieve pain with cold

Everyone is familiar with the idea of using cold for pain relief. But iovera° is an innovative treatment that uses cold like no other therapy. iovera° is a type of treatment known as cryoneurolysis (kri-o-nuh-rol-i-sis), or cold therapy, to achieve cryoanalgesia (kri-o-an-al-je-ze-a).

iovera° targets the nerves

The iovera° system is a handheld device that allows your doctor to target specific nerves with just the right amount of cold. This temporarily stops the nerves from sending pain signals. iovera° is precise and safe—it cannot damage surrounding tissue.

You will feel immediate relief after treatment.


See the iovera° system in action.

You can learn more about what to expect at your appointment.

Ready to talk with a doctor about iovera°?


iovera° applies freezing cold to peripheral nerve tissue to block and/or relieve pain for up to 90 days. It should not be used to treat central nervous system tissue.

Important Safety Information

The iovera° system should not be used in people with the following conditions:

  • Do not receive treatment with ioveraº if you experience hypersensitivity to cold or have open and/or infected wounds near the treatment site.
  • You may experience bruising, swelling, inflammation and/or redness, local pain and/or tenderness, and altered feeling at the site of application.
  • In treatment area(s), you may experience damage to the skin, skin darkening or lightening, and dimples in the skin.
  • You may experience a temporary loss of your ability to use your muscles normally outside of the treatment area.
  • Talk to your doctor before receiving treatment with ioveraº.
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The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain.

Important Safety Information