Videos and assets detailing both the basics of iovera°, such as how to set up the system and the mechanism of action (MOA), as well as more specific information, such as procedural protocols.

How iovera Fits with the Treatment of TKA Pain

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Dr Pieter Vreede differentiated between Total Knee Arthroplasty immediate post-operative pain commonly treated by short-term blocks, versus chronic pain in the knee treated with iovera˚.

Modalities Affecting Pain in the Body

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Dr Vinod Dasa on adopting multimodal protocols to treat pain at various stages along the pain pathway.

History of Cryotechnology and Introduction of the iovera System

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Dr Vinod Dasa introduces the use and history of cryotherapy, also known as cryoneurolysis, and how iovera˚ targeted cold therapy using nitrous oxide provides a safe and effective treatment option at -88˚C.

Considering Knee Anatomy for Treatment of Pain

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Dr Pieter Vreede identifies the stretch of an incision site after total knee arthroplasty as a core component to the pain experienced by a patient during postsurgical recovery.

Nerve Anatomy Related to the iovera MOA Versus Other Modalities

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Dr Vinod Dasa discusses the endoneurium, perineurium, and epineurium anatomical nerve structures as well as the Sunderland nerve injury classifications in relation to commonly used cryotechnologies.

Efficacy and Safety of iovera

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Dr Vinod Dasa describes the effect and safety profile of cryoanalgesia treatment with iovera˚ on surrounding tissue and vascular structures in the body.

Comparative Technology Guide


A side-by-side educational comparison of available thermal neurolytic treatments. Details on the clinical application, mechanism of action, safety profile and more for each of cryoablation, cryoneurolysis, and cooled/conventional radiofrequency (RF) ablation.

System Setup Guide


Instructions on setup, priming, attaching Smart Tips, and replacing Cartridges. Please see the full user guide for detailed instructions.

MOA Video


The iovera° treatment works by applying targeted cold to a peripheral nerve. The effect of this treatment is immediate and can last up to 90 days.

Superficial Genicular Pre-TKA Case Report With Smart Tip 190

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A case report featuring Dr Josh Urban performing superficial genicular treatment prior to a Total Knee Arthroplasty using the Smart Tip 190 under ultrasound.

IndicationThe iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain. It is also indicated for the relief of pain and symptoms associated with osteoarthritis of the knee for up to 90 days. The iovera° system is not indicated for treatment of central nervous system tissue. The iovera° system’s “1x90” Smart Tip configuration (indicating one needle which is 90 mm long) can also facilitate target nerve location by conducting electrical nerve stimulation from a separate nerve stimulator.

Important Safety Information

ContraindicationsThe iovera° system is contraindicated for use in patients with the following:

  • Cryoglobulinemia, paroxysmal cold hemoglobinuria, cold urticaria, Raynaud’s disease, and open and/or infected wounds at or near the treatment site

Potential ComplicationsAs with any surgical treatment that uses needle-based therapy and local anesthesia, there is a potential for site-specific reactions, including, but not limited to:

  • Ecchymosis, edema, erythema, local pain and/or tenderness, and localized dysesthesia

Proper use of the device as described in the User Guide can help reduce or prevent the following complications:

  • At the treatment site(s): injury to the skin related to application of cold or heat, hyper- or hypopigmentation, and skin dimpling
  • Outside the treatment site(s): loss of motor function